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Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Updated: Jul 20, 2025

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Temporal Optic Disc Microvasculature Dropout in Glaucoma.

Yeon Ju Lim¹, Jong Wook Bang¹, Robert N Weinreb²

¹Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

Investigative Ophthalmology & Visual Science

|August 4, 2023

Summary

This summary is machine-generated.

Focal temporal microvasculature dropout in primary open-angle glaucoma is linked to longer axial length and optic disc changes. This suggests axial elongation may cause temporal optic disc microvasculature absence.

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Published on: February 18, 2022

Area of Science:

Ophthalmology
Glaucoma Research
Optical Coherence Tomography Angiography

Background:

Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
Microvasculature dropout (MvD-D) in the optic disc is an early sign of glaucoma progression.
Understanding the patterns of MvD-D, particularly in the temporal region, is crucial for diagnosis and management.

Purpose of the Study:

To investigate the clinical characteristics of focal temporal optic disc microvasculature dropout (MvD-D) in patients with primary open-angle glaucoma (POAG).
To differentiate between isolated focal temporal MvD-D and other patterns of temporal MvD-D.

Main Methods:

187 eyes of POAG patients with MvD-D on Swept-Source optical coherence tomography angiography (SS-OCTA) were analyzed.
Patients were categorized into three groups based on temporal MvD-D patterns: focal (Group 1), supero/inferotemporal (Group 2), and diffuse temporal (Group 3).
Clinical characteristics including axial length, parapapillary atrophy, optic disc morphology, and retinal nerve fiber layer (RNFL) thickness were compared across groups.

Main Results:

Group 1 (focal temporal MvD-D) showed significantly longer axial length, larger β-zone parapapillary atrophy, greater horizontal tilt, and ovality index compared to other groups.
Group 1 also had thinner temporal RNFL compared to Group 2, despite similar thicknesses in other sectors.
Group 3 (diffuse temporal MvD-D) exhibited significantly worse visual field mean deviation and thinner RNFL in most sectors compared to Groups 1 and 2.

Conclusions:

Focal temporal MvD-D in POAG is associated with increased axial length and subsequent optic disc morphological changes.
Axial elongation appears to be a significant factor contributing to the absence of temporal optic disc microvasculature.
These findings highlight the importance of SS-OCTA in identifying specific MvD-D patterns and their correlation with glaucoma severity and underlying structural changes.