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In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus
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Powassan Virus Encephalitis: A Tertiary Center Experience

Maria Alejandra Mendoza1, Reece M Hass2, James Vaillant1

  • 1Division of Public Health, Infectious Diseases, and Occupational Medicine News, Mayo Clinic, Rochester, Minnesota, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 4, 2023
PubMed
Abstract

Insights

Powassan virus (POWV) causes severe neuroinvasive disease. This study found high rates of death and long-term disability in POWV patients, emphasizing the need for early diagnosis.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Public Health

Background:

  • Powassan virus (POWV) is an emerging tick-borne flavivirus.
  • POWV infection is associated with severe neuroinvasive disease and poor patient outcomes.

Purpose of the Study:

  • To analyze clinical and epidemiological data of neuroinvasive POWV cases.
  • To describe the presentation, diagnosis, and outcomes of neuroinvasive POWV.

Main Methods:

  • Retrospective study at Mayo Clinic (2013-2022).
  • Inclusion of probable and confirmed neuroinvasive POWV cases.
  • Analysis of clinical and epidemiological data.

Main Results:

  • Sixteen patients with neuroinvasive POWV were identified.
  • Common presentations included rhombencephalitis, meningitis, and encephalitis.
  • High rates of mortality (18.8%) and residual neurologic deficits (72.7%) were observed.

Conclusions:

  • This is the largest case series of neuroinvasive POWV infection.
  • High clinical suspicion is crucial for patients in high-risk areas during warmer months.
  • Neuroinvasive POWV is associated with significant morbidity and mortality.
Keywords:
Powassan virusarbovirustick-borne diseases

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