Pacemaker-lead-associated thrombosis in dogs: a multicenter retrospective study.
Summary
Pacemaker-lead-associated thrombosis (PLAT) affects 10.4% of dogs with transvenous pacemakers. This condition is linked to proteinuria and reduced survival times in canine patients.
Area of Science:
- Veterinary Cardiology
- Thrombosis Research
- Medical Device Complications
Background:
- Pacemaker implantation is standard for bradyarrhythmias.
- Pacemaker-lead-associated thrombosis (PLAT) affects 23.0-45.0% of humans with transvenous pacemakers.
- The incidence of PLAT in dogs is currently unknown.
Purpose of the Study:
- To determine the incidence of PLAT in dogs.
- To identify risk factors and clinical outcomes associated with PLAT in dogs.
- To evaluate the association between PLAT and proteinuria.
Main Methods:
- A multicenter retrospective study involving 606 dogs undergoing pacemaker implantation (2012-2019).
- Analysis of 260 dogs with transvenous pacemakers and echocardiographic follow-up.
- Assessment of proteinuria using urine protein:creatinine ratio.
Main Results:
- PLAT was identified in 10.4% (27/260) of dogs with transvenous pacemakers and echocardiographic follow-up.
- Dogs with PLAT were more likely to have proteinuria at pacemaker implantation (100.0% vs. 40.4%).
- Dogs with PLAT had significantly shorter survival times compared to those without PLAT (677 days vs. 1105 days).
Conclusions:
- PLAT occurs in 10.4% of dogs following transvenous pacing.
- PLAT in dogs is associated with proteinuria and reduced survival times.
- PLAT can cause significant morbidity in canine patients.
