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INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement: Imaging recommendations for the
Reineke A Schoot1, Roelof van Ewijk1, Anna-Anais von Witzleben2
1Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Insights
International collaboration through INSTRuCT has established consensus imaging guidelines for pediatric rhabdomyosarcoma. Standardized imaging aims to improve clinical trial comparisons and accelerate survival improvements for this rare cancer.
Area of Science:
- Pediatric Oncology
- Medical Imaging
- Sarcoma Research
Background:
- Rhabdomyosarcoma is the most common pediatric soft-tissue cancer.
- Survival rates, especially for metastatic disease, have seen minimal improvement.
- The rarity of rhabdomyosarcoma hinders clinical trial progress.
Purpose of the Study:
- To establish international consensus recommendations for imaging in pediatric rhabdomyosarcoma.
- To promote standardized diagnostic, staging, and follow-up imaging protocols.
- To facilitate international cooperation and accelerate research for improved survival.
Main Methods:
- Formation of the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) in 2017.
- Development of international consensus statements by multidisciplinary members.
- Focus on imaging recommendations by the INSTRuCT Diagnostic Imaging Working Group.
Main Results:
- International consensus recommendations for imaging pediatric rhabdomyosarcoma have been developed.
- Standardized imaging protocols are proposed for diagnosis, staging, and therapy monitoring.
- The goal is to enable reliable international comparison of clinical trial results.
Conclusions:
- Standardized imaging is crucial for advancing rhabdomyosarcoma research.
- International consensus facilitates more robust clinical trial data.
- Improved management and survival for pediatric rhabdomyosarcoma are anticipated.
Abstract:
Rhabdomyosarcoma is the most common soft-tissue neoplasm in the pediatric population. The survival of children with rhabdomyosarcoma has only marginally improved over the past 25 years and remains poor for those with metastatic disease. A significant challenge to advances in treatment of rhabdomyosarcoma is the relative rarity of this disease, necessitating years to complete clinical trials. Progress can be accelerated by international cooperation and sharing national experiences. This necessitates agreement on a common language to describe patient cohorts and consensus standards to guide diagnosis, treatment, and response assessment. These goals formed the premise for creating the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) in 2017. Multidisciplinary members of this consortium have since developed international consensus statements on the diagnosis, treatment, and management of pediatric soft-tissue sarcomas. Herein, members of the INSTRuCT Diagnostic Imaging Working Group present international consensus recommendations for imaging of patients with rhabdomyosarcoma at diagnosis, at staging, and during and after completion of therapy. The intent is to promote a standardized imaging approach to pediatric patients with this malignancy to create more-reliable comparisons of results of clinical trials internationally, thereby accelerating progress in managing rhabdomyosarcoma and improving survival.
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