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Replacing microglia to treat Alzheimer's disease
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Cell Stem Cell
|August 4, 2023
Abstract:
In this issue of Cell Stem Cell, Yoo et al.1 report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.

