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Liver X receptors: From pharmacology to nanoparticle-based drug delivery

Xiaofen Hua1, Xiduan Wei2

  • 1Department of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, James Clerk Maxwell Building, 57 Waterloo Road, London, SE1 8WA, UK.

European Journal of Pharmacology
|August 4, 2023
PubMed

Insights

Liver X receptors (LXRs) regulate key biological processes. This review covers LXR modulators and nanoparticle delivery systems for treating diseases like atherosclerosis and cancer.

Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Liver X receptors (LXRs) are nuclear oxysterol receptors crucial for metabolism, inflammation, development, and reproduction.
  • LXRs comprise two subtypes: LXRα (NR1H3) and LXRβ (NR1H2).
  • LXR modulators (agonists and antagonists) have been developed since the mid-1990s for treating diseases like atherosclerosis, lupus, and cancer.

Purpose of the Study:

  • To review current understanding of LXR biology and pharmacology.
  • To focus on the development of selective LXR modulators (subtype-, cell-, or tissue-specific).
  • To explore nanoparticle-based delivery systems for enhancing LXR drug clinical potential.

Main Methods:

  • Literature review of LXR biology and pharmacology.
  • Analysis of LXR modulator development strategies.
  • Examination of nanoparticle delivery systems for LXR drugs.

Main Results:

  • Significant progress in designing selective LXR modulators.
  • Emerging potential of nanoparticle-based delivery systems for LXR therapeutics.
  • LXR modulators show promise for treating metabolic, inflammatory, and oncological diseases.

Conclusions:

  • LXR modulators represent a promising therapeutic strategy for various diseases.
  • Nanoparticle delivery systems are key to improving the clinical application of LXR drugs.
  • Further research into LXR biology and targeted delivery will advance LXR-based therapies.
Keywords:
BiologicsDrug deliveryLiver X receptorsNanoparticlesPharmacology

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