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Updated: Jul 20, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
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Glucose metabolism disorder: a potential accomplice of SARS-CoV-2

Yi Luan1, Ying Luan2, Hongbo He3

  • 1Department of Translational Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

International Journal of Obesity (2005)
|August 4, 2023
PubMed

Insights

This review highlights how diabetes and glucose metabolism disorders worsen SARS-CoV-2 (CoV-2) infection outcomes. Targeting these metabolic issues may offer new treatments for severe CoV-2 disease.

Area of Science:

  • Metabolic Medicine
  • Infectious Diseases
  • Molecular Biology

Background:

  • Over 265 million SARS-CoV-2 (CoV-2) cases and 5.2 million deaths reported globally.
  • Individuals with type 2 diabetes mellitus (T2DM) face increased risk of severe CoV-2 infection.
  • Established link between glucose metabolism and CoV-2 progression.

Purpose of the Study:

  • To review the association between glucose metabolism disorders and CoV-2 progression.
  • To elucidate the impact of diabetes on CoV-2 severity.
  • To identify therapeutic targets within glucose metabolism for CoV-2 treatment.

Main Methods:

  • Literature review synthesizing evidence on glucose metabolism and CoV-2.
  • Analysis of key proteins and pathways regulating glucose metabolism.
  • Exploration of potential interventions targeting metabolic disorders.

Main Results:

  • Glucose metabolism disorders, including T2DM, promote severe CoV-2 progression.
  • Specific proteins and pathways in glucose metabolism significantly influence CoV-2 outcomes.
  • Targeting metabolic dysregulation presents a promising therapeutic strategy.

Conclusions:

  • Dysregulated glucose metabolism exacerbates SARS-CoV-2 (CoV-2) infection.
  • Interventions aimed at glucose metabolism disorders could be crucial for managing CoV-2.
  • This review offers a metabolic perspective for CoV-2 treatment strategies.

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