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The mechanisms, functions and clinical applications of miR-542-3p in human cancers

Shadia Hamoud Alshahrani1, Nodir Rakhimov2, Jitendra Gupta3

  • 1Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.

Pathology, Research and Practice
|August 5, 2023
PubMed

Insights

MicroRNA-542-3p (miR-542-3p) is frequently downregulated in cancers and impacts tumor progression by regulating key pathways. Its aberrant expression correlates with poor prognosis, highlighting its role in cancer pathogenesis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (noncoding RNAs) are vital in development.
  • miR-542-3p is notably decreased in various cancers.
  • Its dysregulation is linked to cancer progression.

Purpose of the Study:

  • To review the biogenesis, function, and regulation of miR-542-3p.
  • To explore its aberrant expression in neoplastic cells.
  • To discuss its prognostic value and molecular mechanisms in cancer.

Main Methods:

  • Literature review and synthesis of existing data.
  • Analysis of miR-542-3p's role in cancer-related pathways.
  • Examination of upstream regulatory mechanisms.

Main Results:

  • miR-542-3p targets over 18 genes and impacts pathways (Wnt/β-catenin, ERK1/2, JAK2, PI3K/AKT).
  • It influences cancer behaviors including metastasis, EMT, and apoptosis.
  • Upregulation of miR-542-3p or related RNAs is associated with poor patient prognosis.

Conclusions:

  • miR-542-3p is a significant tumor suppressor microRNA.
  • Its dysregulation and molecular functions are critical in cancer development.
  • miR-542-3p holds potential as a prognostic biomarker and therapeutic target.
Keywords:
CancerPrognosismiR-542-3pmicroRNA

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