Related Experiment Video

Updated: Jul 20, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.5K

ETS transcription factor ELK3 in human cancers: An emerging therapeutic target

Sulieman Ibraheem Shelash Al-Hawary1, Harikumar Pallathadka2, Ahmed Hjazi3

  • 1Department of Bussiness Adminstration, Bussiness School, Al al-Bayt University, P.O.BOX 130040, Mafraq 25113, Jordan.

Pathology, Research and Practice
|August 5, 2023
PubMed

Insights

The transcription factor ELK3 (ELK3) promotes cancer progression by enhancing cell invasion, migration, and proliferation while suppressing apoptosis. ELK3 may serve as a diagnostic biomarker and chemoresistance mediator in human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is a complex genetic disorder involving tumor suppressors and oncogenes that regulate tumor progression.
  • Transcription factors (TFs) play crucial roles as either tumor suppressors or oncogenes.
  • The E-twenty-six/E26 (ETS) family of TFs, including ELK3, are implicated in cancer development and progression.

Purpose of the Study:

  • To investigate the role of ELK3 in human cancers.
  • To explore the molecular mechanisms underlying ELK3's function in cancer.
  • To evaluate ELK3 as a potential diagnostic and prognostic biomarker and chemoresistance mediator.

Main Methods:

  • Analysis of ELK3 expression and its correlation with cancer hallmarks.
  • Investigation of ELK3's impact on cell invasion, migration, proliferation, cell cycle, EMT, and apoptosis.
  • Assessment of ELK3's potential as a biomarker and its role in chemoresistance.

Main Results:

  • ELK3 expression is elevated in various cancers, suggesting an oncogenic role.
  • ELK3 promotes invasion, migration, cell cycle progression, proliferation, and epithelial-mesenchymal transition (EMT).
  • ELK3 suppresses apoptosis and acts as a chemoresistance mediator.

Conclusions:

  • ELK3 is an oncogenic transcription factor that drives cancer progression.
  • ELK3 holds promise as a diagnostic and prognostic biomarker in human cancers.
  • ELK3 may mediate chemoresistance, offering potential therapeutic targets.
Keywords:
CancerE-twenty-six/E26ELK3Oncogene

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.9K
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.3K

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
9.9K
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.4K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
76.1K