Related Experiment Video
Updated: Jul 20, 2025

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
Solution NMR investigations of integral membrane proteins: Challenges and innovations
Matthew Necelis1, Connor McDermott1, Meagan Belcher Dufrisne1
1Department of Chemistry, University of Virginia, Charlottesville, VA, USA.
Abstract:
Compared to soluble protein counterparts, the understanding of membrane protein stability, solvent interactions, and function are not as well understood. Recent advancements in labeling, expression, and stabilization of membrane proteins have enabled solution nuclear magnetic resonance spectroscopy to investigate membrane protein conformational states, ligand binding, lipid interactions, stability, and folding. This review highlights these advancements and new understandings and provides examples of recent applications.
More Related Videos
09:25Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
14:55Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Related Concept Videos
Applications Of NMR In Biology
Single-pass Transmembrane Proteins
¹H NMR Signal Integration: Overview