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Published on: August 4, 2021
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Dysregulated miRNAs in recurrent miscarriage: A systematic review
Parvin Hakimi1, Fatemeh Tabatabaei2, Vahideh Rahmani1
1Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Gene
|August 5, 2023
Summary
MicroRNA (miRNA) expression changes are linked to recurrent miscarriage (RM). This review identifies 61 dysregulated miRNAs, offering insights into RM
Area of Science:
- Reproductive Medicine
- Genetics
- Molecular Biology
Background:
- Recurrent miscarriage (RM) affects numerous families, with unclear etiology.
- MicroRNAs (miRNAs) are implicated in various diseases, potentially including RM.
- Understanding miRNA dysregulation is crucial for clarifying RM pathogenesis.
Approach:
- A systematic review following Prisma guidelines was conducted.
- Seven databases were searched, yielding 245 articles.
- Thirty-nine studies met inclusion criteria for analysis.
Key Points:
- A total of 61 dysregulated miRNAs were identified in RM.
- 40 miRNAs were found to be up-regulated (65.57%).
- 21 miRNAs were found to be down-regulated (34.43%).
Conclusions:
- Dysregulated miRNAs impact RM pathophysiology via apoptosis, angiogenesis, epithelial-mesenchymal transition, and immune responses.
- Identifying specific miRNA roles can elucidate RM mechanisms.
- This knowledge may lead to novel therapeutic targets for RM.
