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Updated: Jul 20, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Intestinal perforation with systemic lupus erythematosus: A systematic review
Ya Lan Chen1, Jie Meng1, Cong Li2
1Department of Gastroenterology, The Affiliated Hospital of Hebei University, Baoding, P.R. China.
Intestinal perforation in systemic lupus erythematosus (SLE) is rare but deadly. Early diagnosis, steroid therapy, and prompt surgery are crucial for managing this severe SLE complication.
Area of Science:
- Gastroenterology
- Rheumatology
- Surgical Pathology
Background:
- Intestinal perforation (IP) is a rare but life-threatening complication of systemic lupus erythematosus (SLE).
- Timely diagnosis and treatment are essential for improving outcomes in SLE patients with IP.
Conclusions:
- IP in SLE is associated with long disease duration, high activity, and other immune conditions.
- Lupus mesenteric vasculitis is a primary cause, frequently affecting the rectum.
- Early diagnosis, resuscitation, antibiotics, steroids, and prompt surgery are vital for successful management.
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