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Factor V inhibitor associated with immune complex formation.

J Lazarchick, C M Wolff, S H Pepkowitz

Archives of Pathology & Laboratory Medicine

|May 1, 1986

Summary

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A patient developed a rare bleeding disorder due to a high-titer anti-factor V inhibitor after surgery. Steroid therapy resolved the immune complexes and bleeding diathesis.

Area of Science:

Hematology
Immunology
Internal Medicine

Background:

Acquired factor inhibitors can cause significant bleeding complications.
Factor V inhibitors are rare but can lead to severe hemostatic defects.

Observation:

A 72-year-old male presented with a bleeding diathesis post-surgery.
The bleeding was attributed to the development of a high-titer inhibitor against factor V.

Findings:

Factor V:anti-factor V IgG immune complexes were identified in the patient's plasma.
Immune complex levels decreased after a brief course of steroid treatment.

Implications:

This case highlights the importance of considering acquired factor inhibitors in post-operative bleeding.

Related Experiment Videos

Steroid therapy can be effective in managing factor V inhibitors by clearing immune complexes.

Understanding the immunopathogenesis of acquired factor inhibitors is crucial for effective treatment strategies.