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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Regulation of the Cardiovascular System01:27

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
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Crafting a Blueprint for MicroRNA in Cardiovascular Diseases (CVDs).

Shahid Ullah Khan1, Sumbul Saeed2, Ayesha Nazir Sheikh3

  • 1Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China; Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing, 400715, China; Women Medical and Dental College, Khyber Medical University, Peshawar, KPK, 22020, Pakistan.

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MicroRNAs (miRNAs) are key regulators in cardiovascular diseases (CVDs). Understanding miRNA roles offers new diagnostic and therapeutic strategies for heart conditions.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are the leading cause of global mortality, despite therapeutic advances.
  • Gene and microRNA (miRNA) expression changes critically affect cellular pathways and disease development.
  • MiRNAs are crucial gene regulators involved in essential cellular processes and various diseases, including CVD.

Purpose of the Study:

  • To review the latest advancements in microRNA identification and characterization.
  • To explore the manipulation and clinical applications of miRNAs in cardiovascular diseases.
  • To discuss future perspectives on microRNA research in CVD.

Main Methods:

  • Literature review of recent studies on microRNAs in cardiovascular diseases.
  • Analysis of gene and miRNA expression patterns in CVD.
  • Exploration of diagnostic and therapeutic strategies involving miRNAs.

Main Results:

  • Evidence strongly supports the involvement of miRNAs in the progression of cardiovascular diseases.
  • MicroRNAs demonstrate potential as valuable diagnostic biomarkers for CVD.
  • MiRNA-based therapies offer promising new avenues for treating cardiovascular conditions.

Conclusions:

  • MicroRNAs play significant roles in cardiovascular disease pathogenesis.
  • Further research into miRNAs can lead to improved diagnostics and treatments for CVD.
  • Targeting miRNAs presents a promising future for cardiovascular medicine.