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Updated: Jul 20, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Crafting a Blueprint for MicroRNA in Cardiovascular Diseases (CVDs)

Shahid Ullah Khan1, Sumbul Saeed2, Ayesha Nazir Sheikh3

  • 1Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China; Engineering Research Center of South Upland Agriculture, Ministry of Education, Chongqing, 400715, China; Women Medical and Dental College, Khyber Medical University, Peshawar, KPK, 22020, Pakistan.

Current Problems in Cardiology
|August 6, 2023
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cardiovascular diseases (CVDs). Understanding miRNA roles offers new diagnostic and therapeutic strategies for heart conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are the leading cause of global mortality, despite therapeutic advances.
  • Gene and microRNA (miRNA) expression changes critically affect cellular pathways and disease development.
  • MiRNAs are crucial gene regulators involved in essential cellular processes and various diseases, including CVD.

Purpose of the Study:

  • To review the latest advancements in microRNA identification and characterization.
  • To explore the manipulation and clinical applications of miRNAs in cardiovascular diseases.
  • To discuss future perspectives on microRNA research in CVD.

Main Methods:

  • Literature review of recent studies on microRNAs in cardiovascular diseases.
  • Analysis of gene and miRNA expression patterns in CVD.
  • Exploration of diagnostic and therapeutic strategies involving miRNAs.

Main Results:

  • Evidence strongly supports the involvement of miRNAs in the progression of cardiovascular diseases.
  • MicroRNAs demonstrate potential as valuable diagnostic biomarkers for CVD.
  • MiRNA-based therapies offer promising new avenues for treating cardiovascular conditions.

Conclusions:

  • MicroRNAs play significant roles in cardiovascular disease pathogenesis.
  • Further research into miRNAs can lead to improved diagnostics and treatments for CVD.
  • Targeting miRNAs presents a promising future for cardiovascular medicine.

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