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B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cells
Zhe Yang1,2, Zheng Wang3, Lei Wu1,2
1Institute of Translational Medicine, Yangzhou University Medical College, Yangzhou, China.
Frontiers in Immunology
|August 7, 2023
Summary
Certain B lymphocytes can transform into immunosuppressive erythroid progenitor cells (EPCs) under stress. Targeting these specific B cells may offer a novel cancer therapy by restoring immune function.
Area of Science:
- Immunology
- Cell Biology
- Oncology
Background:
- Nucleated cells with erythroid markers (CD45+ EPCs) suppress immunity and promote tumors.
- The origin of these immunosuppressive EPCs remains largely unknown.
Purpose of the Study:
- To investigate the origin of CD45+ EPCs.
- To explore the potential transdifferentiation of B lymphocytes into EPCs.
Main Methods:
- In vitro studies using mouse B lymphoma cells under hypoxic conditions.
- Analysis of non-neoplastic B cells from mice under anemia or tumor conditions.
- Identification of double-positive cells in human chronic lymphocytic leukemia patients.
Main Results:
- Mouse B lymphoma cells converted to erythroblast-like cells (CD45+TER119+) with immunosuppressive properties.
- Non-neoplastic B cells exhibited similar differentiation and immunosuppressive effects.
- CD19+CD235a+ cells were found in human leukemia patients.
Conclusions:
- A subset of CD45+ EPCs originate from B lymphocytes via transdifferentiation.
- B lymphocyte plasticity is influenced by environmental stresses like hypoxia.
- Targeting specific B cells offers a potential therapeutic strategy for cancer and immune restoration.
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