P63 and Ki-67 expression in radicular cyst.

Area of Science:

• Oral pathology
• Molecular biology
• Immunohistochemistry

Background:

• Radicular cysts (RCs) are inflammatory jaw cysts.
• P63 is a transcription factor crucial for epithelial development and maintenance.
• Understanding P63 expression in RCs may elucidate cyst pathogenesis.

Purpose of the Study:

• To investigate P63 expression in radicular cysts.
• To correlate P63 expression with odontogenic epithelial cell proliferation (Ki-67).
• To assess the relationship between P63 and inflammatory infiltrate severity and RC size.

Main Methods:

• Retrospective cross-sectional study of 30 radicular cyst samples.
• Immunohistochemistry used to detect P63 and Ki-67 expression.
• Statistical analysis to correlate marker expression with clinicopathological features.

Main Results:

• High P63 expression observed in both odontogenic epithelium and connective tissue capsule of RCs.
• No correlation found between Ki-67 (proliferation marker) and P63 expression.
• A positive correlation was found between Ki-67 and RC size.
• Negative correlation between inflammatory infiltrate and P63 expression in odontogenic epithelium.
• Negative correlation between inflammatory infiltrate and RC size.

Conclusions:

• P63 is highly expressed in radicular cysts.
• P63 expression in odontogenic epithelium is inversely related to inflammatory infiltrate.
• P63 expression does not correlate with epithelial cell proliferation or RC size.