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Updated: Jul 19, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis
Mo Yuan1,2,3,4,5,6,7, Xiao-Ling Liu8, Ying Tan1,2,3,4,5
1Renal Division, Peking University First Hospital, Beijing, China.
Mediators of Inflammation
|August 7, 2023
Summary
Urinary modified C-reactive protein (mCRP) is elevated in lupus nephritis and indicates tubulointerstitial damage. This suggests urinary mCRP may serve as a biomarker for kidney lesions and poor prognosis in lupus nephritis patients.
Area of Science:
- Nephrology
- Immunology
- Biochemistry
Background:
- Modified C-reactive protein (mCRP) amplifies local inflammatory responses.
- Investigating mCRP's role in lupus nephritis is crucial for understanding disease mechanisms.
Purpose of the Study:
- To examine circulating and local mCRP levels in lupus nephritis.
- To correlate mCRP levels with clinicopathological features and patient outcomes.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) for plasma and urinary mCRP.
- Immunohistochemistry and immunofluorescence for renal mCRP deposition.
- In vitro study using HK2 cells stimulated with lupus nephritis IgG.
Main Results:
- Significantly elevated plasma and urinary mCRP in lupus nephritis patients.
- Urinary mCRP correlated with tubulointerstitial inflammation, fibrosis, and poor prognosis.
- Renal mCRP deposition in tubules, co-localizing with IgG, and induced by lupus nephritis IgG in vitro.
Conclusions:
- Urinary mCRP is a potential biomarker for tubulointerstitial lesions in lupus nephritis.
- Tubular epithelial cells can produce CRP, contributing to renal inflammation in lupus nephritis.
- Local mCRP plays a role in the pathogenesis of tubulointerstitial damage in lupus nephritis.
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