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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

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Coronavirus disease 2019 and cardiovascular disease

Jenn-Yeu Song1,2,3, Jian-You Huang3,4, Yi-Chiung Hsu2

  • 1Division of Cardiovascular Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Tzu Chi Medical Journal
|August 7, 2023
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause myocardial damage in COVID-19 patients. Understanding these cardiovascular effects is crucial for effective treatment and reducing mortality risks.

Area of Science:

  • Cardiology
  • Virology
  • Pathophysiology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19).
  • Cardiovascular diseases (CVDs) are known risk factors for increased mortality.
  • COVID-19 has demonstrated significant cardiovascular manifestations and adverse prognostic impacts.

Purpose of the Study:

  • To review existing evidence on the mechanisms of myocardial damage in COVID-19 patients.
  • To enhance understanding of SARS-CoV-2-induced cardiovascular damage.
  • To inform prompt and efficient treatment strategies for COVID-19 patients with cardiovascular involvement.

Main Methods:

  • Literature review of existing evidence.
  • Analysis of potential mechanisms of myocardial injury.
  • Overview of cardiovascular manifestations and complications in COVID-19.

Main Results:

  • SARS-CoV-2 infection can lead to acute myocardial injury, potentially mediated by the angiotensin-converting enzyme 2 receptor.
  • COVID-19 can exacerbate existing heart failure through increased oxygen demand, myocarditis, stress cardiomyopathy, pulmonary hypertension, and venous thrombosis.
  • Severe COVID-19 may result in cardiogenic shock and acute systolic heart failure.

Conclusions:

  • Comprehensive knowledge of SARS-CoV-2 cardiovascular damage mechanisms is vital for reducing mortality.
  • Treatment options for refractory circulatory support include extracorporeal membrane oxygenation (ECMO) and left ventricular assist devices (LVADs).
  • Continuous monitoring of SARS-CoV-2 evolution and transmissibility is essential for future cardiovascular disease surveillance.

Keywords:
Angiotensin-converting enzyme 2 receptorCardiovascular diseaseCoronavirus disease 2019

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