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Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...

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An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

PROFASA-a web-based protein fragment and structure analysis workstation.

Yanlin Mi^1,2, Stefan-Bogdan Marcu¹, Sabin Tabirca^1,3

¹School of Computer Science and Information Technology, University College Cork, Cork, Ireland.

Frontiers in Bioengineering and Biotechnology

|August 7, 2023

Summary

PROFASA is a new protein workstation simplifying complex bioinformatics tasks. This user-friendly tool integrates protein structure modelling, analysis, and visualisation, making advanced computational biology accessible to more researchers.

Keywords:

bioinformatics computational biology edutainment gamification molecular visualisation protein modeling proteins

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Last Updated: Jul 19, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Area of Science:

Bioinformatics
Computational Biology
Structural Biology

Background:

Protein structure modelling and analysis are vital in bioinformatics.
Existing tools often demand high technical expertise and lack user-friendliness.

Purpose of the Study:

To develop PROFASA, an innovative protein workstation.
To provide a comprehensive, user-friendly platform for protein sequence and structure analyses.

Main Methods:

Integrated state-of-the-art protein structure visualisation techniques.
Incorporated cutting-edge tools and algorithms for protein analysis.
Designed simplified one-click operations with customisation options.

Main Results:

PROFASA enables one-click protein model construction (e.g., I-TASSER, AlphaFold2).
Facilitates protein structure evaluation, parametric analysis, and visualisation.
Offers real-time collaboration, note sharing, and shared projects.

Conclusions:

PROFASA lowers the barrier for entry into protein computation and analysis.
Enhances possibilities for protein research, design, engineering, and education.