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Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
Chidozie N Ndulue1, Nonyelum N Jisieike-Onuigbo1, Nwabueze J Okwesa1
1Department of Medicine, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protective anti-platelet drug used in CKD patients at risk of dyspepsia. However, its potential to cause TTP should be recognized and considered in acute kidney injury (AKI) patients previously on clopidogrel.
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