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Related Experiment Video

Updated: Jul 19, 2025

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
04:19

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

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A New Approach for Explaining and Treating Dry Sockets: A Pilot Retrospective Study.

Wael Khalil1

  • 1Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lebanese University, Beirut, LBN.

Cureus
|August 7, 2023
PubMed
Summary

Dry socket, a painful post-extraction complication, may stem from infection. Treating dry socket with ciprofloxacin showed significant symptom relief in most patients, suggesting an infectious cause.

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Area of Science:

  • Dentistry
  • Oral Surgery
  • Infectious Diseases

Background:

  • Dry socket (alveolar osteitis) is a common, painful complication after tooth extraction.
  • Its exact cause and mechanisms remain unclear despite known risk factors.
  • Current management often involves pain relief and local treatment.

Purpose of the Study:

  • To propose a novel pathogenesis for dry socket based on an infectious process.
  • To evaluate a new management approach for dry socket using antibiotics.

Main Methods:

  • Retrospective review of medical records from a private dental clinic (April 2022-April 2023).
  • Inclusion criteria: patients aged ≥17 with dry socket resistant to conventional treatment.
  • Treatment administered: ciprofloxacin 500 mg TID for patients with dry socket.
Keywords:
alveolar osteitisbacterial biofilmdry socketenterococcus faecalislocalized alveolitispseudomonas aeruginosa

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Last Updated: Jul 19, 2025

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Main Results:

  • 11 out of 15 patients (73.3%) experienced complete symptom relief within 24 hours with ciprofloxacin.
  • Two patients (13.3%) showed partial improvement requiring additional pain management.
  • Two patients (13.3%) did not respond to treatment and were lost to follow-up.

Conclusions:

  • Clinical outcomes support the hypothesis that an infectious mechanism is central to dry socket pathophysiology.
  • Ciprofloxacin treatment demonstrated significant efficacy in managing dry socket symptoms.
  • Findings suggest a potential new treatment strategy for dry socket based on antibiotic therapy.