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Updated: Jul 20, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
Preoperative detection of functional somatostatin receptors in a patient with an insulinoma
Kohei Oguni1, Shinnosuke Fukushima1, Yukichika Yamamoto1
1Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
Abstract:
Octreotide is used in patients with insulinomas to treat hypoglycemia, and somatostatin receptor (SSTR) 2 expression is important for its efficacy. We report a case of insulinoma in a 50-year-old woman that responded to an octreotide test, showed accumulation in somatostatin scintigraphy, and was positive for SSTR2A on immunostaining.
Insights
Octreotide effectively treats hypoglycemia in insulinoma patients by targeting somatostatin receptor 2 (SSTR2). This case study confirms SSTR2A positivity in an insulinoma, validating octreotide efficacy.
Area of Science:
- Endocrinology
- Oncology
- Nuclear Medicine
Background:
- Insulinomas cause hypoglycemia, often managed with octreotide.
- Octreotide efficacy relies on somatostatin receptor 2 (SSTR2) expression.
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