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Benzophenones-natural metabolites with great Hopes in drug discovery: structures, occurrence, bioactivities, and

Sabrin R M Ibrahim1,2, Duaa Fahad ALsiyud3, Abdulrahman Y Alfaeq4

  • 1Preparatory Year Program, Department of Chemistry, Batterjee Medical College Jeddah 21442 Saudi Arabia sabrin.ibrahim@bmc.edu.sa +966-581183034.

RSC Advances
|August 7, 2023
PubMed

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In general, the term ‘aromatic’ indicates a pleasant smell or fragrance from fresh flowers, freshly prepared coffee, etc. In the early history of organic chemistry, many benzene derivatives were isolated from the pleasant odor oils of the plants. For example, vanillin was isolated from the oil of vanilla, methyl salicylate from the oil of wintergreen, and cinnamaldehyde from the oil of cinnamon. They all had a pleasant odor; hence the name aromatic was given.
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Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
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