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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circulating circRNA: a social butterfly in tumors
Shuo Miao1,2, Qingsong Zhang1
1Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in Oncology
|August 7, 2023
Summary
Circular RNAs (circRNAs) are stable molecules in blood that communicate between cells. This review explores their role in cancer development and potential as biomarkers.
Area of Science:
- Molecular Biology
- Cancer Research
- Biochemistry
Background:
- Circular RNAs (circRNAs) are non-coding RNAs with a unique structure.
- Aberrant circRNA expression is linked to various cancers.
- Circulating circRNAs in blood are highly stable and show promise as biomarkers.
Purpose of the Study:
- To review recent findings on cell-cell communication mediated by circulating circRNAs.
- To explore the role of circulating circRNAs in tumor pathological processes.
- To highlight the application value of circulating circRNAs in cancer.
Main Methods:
- Literature review of recent studies on circRNAs in cancer.
- Analysis of mechanisms of cell-cell communication involving circulating circRNAs.
- Synthesis of current knowledge on circRNAs as cancer biomarkers and therapeutic targets.
Main Results:
- Circulating circRNAs mediate intercellular communication in tumors.
- These molecules influence tumorigenesis, immunity, angiogenesis, and metastasis.
- Their stability and regulatory roles underscore their biomarker potential.
Conclusions:
- Circulating circRNAs play a significant role in tumor progression via cell communication.
- Understanding these mechanisms can enhance their utility as cancer biomarkers.
- Circulating circRNAs represent promising targets for cancer therapy.
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