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Published on: December 9, 2016
RDRGSE: A Framework for Noncoding RNA-Drug Resistance Discovery by Incorporating Graph Skeleton Extraction and
Ping Zhang1, Zilin Wang1, Weicheng Sun1
1Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Abstract:
Identifying noncoding RNAs (ncRNAs)-drug resistance association computationally would have a marked effect on understanding ncRNA molecular function and drug target mechanisms and alleviating the screening cost of corresponding biological wet experiments. Although graph neural network-based methods have been developed and facilitated the detection of ncRNAs related to drug resistance, it remains a challenge to explore a highly trusty ncRNA-drug resistance association prediction framework, due to inevitable noise edges originating from the batch effect and experimental errors. Herein, we proposed a framework, referred to as RDRGSE (RDR association prediction by using graph skeleton extraction and attentional feature fusion), for detecting ncRNA-drug resistance association. Specifically, starting with the construction of the original ncRNA-drug resistance association as a bipartite graph, RDRGSE took advantage of a bi-view skeleton extraction strategy to obtain two types of skeleton views, followed by a graph neural network-based estimator for iteratively optimizing skeleton views aimed at learning high-quality ncRNA-drug resistance edge embedding and optimal graph skeleton structure, jointly. Then, RDRGSE adopted adaptive attentional feature fusion to obtain final edge embedding and identified potential RDRAs under an end-to-end pattern. Comprehensive experiments were conducted, and experimental results indicated the significant advantage of a skeleton structure for ncRNA-drug resistance association discovery. Compared with state-of-the-art approaches, RDRGSE improved the prediction performance by 6.7% in terms of AUC and 6.1% in terms of AUPR. Also, ablation-like analysis and independent case studies corroborated RDRGSE generalization ability and robustness. Overall, RDRGSE provides a powerful computational method for ncRNA-drug resistance association prediction, which can also serve as a screening tool for drug resistance biomarkers.
