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Updated: Jul 19, 2025

10:56
Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Published on: May 17, 2014
68.7K
Ribosome Heterogeneity in Development and Disease.
Biorxiv : the Preprint Server for Biology
|August 7, 2023
Summary
Ribosome protein ratios reveal significant cellular differences across tissues, development, and disease. This ribosome ratio-omics barcode highlights functional specialization in various biological contexts.
Area of Science:
- Molecular Biology
- Proteomics
- Cellular Biology
Background:
- The ribosome, a complex molecular machine essential for protein synthesis, comprises approximately 80 distinct proteins.
- Understanding the precise stoichiometry and heterogeneity of ribosome composition is crucial for deciphering cellular function.
Conclusions:
- Ribosome ratio-omics provides a holistic signature of ribosome composition, revealing functional heterogeneity.
- The Ribosome R barcode is a powerful tool for understanding ribosome specialization in cell function, development, and disease.
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