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Updated: Jul 19, 2025

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes.
Biorxiv : the Preprint Server for Biology
|August 7, 2023
Summary
Urine analysis reveals distinct secreted and extracellular vesicle (EV) proteomes. This study shows urinary EVs accurately reflect tissue proteomes, aiding in non-invasive prostate cancer detection and risk stratification.
Area of Science:
- Biochemistry
- Urology
- Proteomics
Background:
- Urine is a complex biofluid reflecting physiological and genitourinary tissue status.
- Urine contains both secreted proteins and proteins within tissue-derived extracellular vesicles (EVs).
Conclusions:
- Urinary EVs are valuable surrogates for tissue proteomic analysis.
- The combined analysis of secreted and EV proteomes offers synergistic value for biomarker discovery and translational research.
- Urinary proteomic profiling provides a non-invasive method for prostate cancer diagnosis and risk assessment.
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