Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Cell Migration01:19

Cell Migration

4.9K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasensitive, simultaneous detection of two biomarkers with a localized surface plasmon resonance biosensor.

The Analyst·2026
Same author

Carfilzomib Induces Cardiotoxicity by Blocking Autophagic Flux Through the cGAS-STING Signaling Pathway.

Biomolecules·2026
Same author

A novel prenylflavonoid with efficacy in cancer therapy by targeting ceramide-orchestrated signaling.

Frontiers in pharmacology·2026
Same author

Ultrasensitive, Selectivity Detection of Mercury Ion Using a Novel Localized Surface Plasmon Resonance Biosensor.

Sensors (Basel, Switzerland)·2026
Same author

A synthetic cell microreactor with two types of interacting dynamic DNA-based pores.

Nature chemistry·2026
Same author

Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in <i>C. elegans</i>.

Cells·2026

Related Experiment Video

Updated: Jul 19, 2025

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
08:53

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

658

Matrix confinement modulates 3D spheroid sorting and burst-like collective migration.

Grace Cai1, Xinzhi Li2, Shan-Shan Lin3

  • 1Applied Physics Program, University of Michigan, Ann Arbor, MI, USA.

Biorxiv : the Preprint Server for Biology
|August 7, 2023
PubMed
Summary

Matrix confinement influences cell sorting and migration in 3D spheroids. High confinement causes cell sorting, while reduced confinement promotes collective cell motion, impacting tumor invasion and metastasis.

Keywords:
3D cell culturecancer invasioncell–cell adhesionhydrogels

More Related Videos

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.6K

Related Experiment Videos

Last Updated: Jul 19, 2025

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
08:53

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

658
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.6K

Area of Science:

  • Biophysics
  • Cancer Biology
  • Cellular Mechanics

Background:

  • Differential cell adhesion drives segregation and sorting in cellular systems.
  • The physical forces governing tumor cell sorting and invasion within the tumor microenvironment are not fully understood.

Conclusions:

  • Matrix confinement modulates 3D spheroid sorting and unjamming in an adhesion-dependent manner.
  • The balance between cell-generated forces and matrix resistance dictates spheroid sorting and invasion.
  • Findings provide insights into mechanisms of cell sorting and migration in primary tumors and metastasis.