Related Experiment Video
Updated: Jul 19, 2025
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
12.7K
Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome
Biorxiv : the Preprint Server for Biology
|August 7, 2023
Summary
Mechanical forces on CD40-CD40L bonds enhance B cell signaling and antibody class-switch. Mutations causing X-linked Hyper IgM syndrome disrupt this mechanobiology, impairing immune responses.
Area of Science:
- Immunology
- Biophysics
- Cellular Mechanobiology
Background:
- B cell maturation in germinal centers relies on T and B cell interactions via CD40-CD40 ligand (CD40L).
- CD40 signaling, alongside B cell receptor (BCR) signaling, is crucial for antibody affinity maturation and class-switch.
- Mutations in CD40L cause X-linked Hyper IgM syndrome (X-HIgM), leading to aberrant antibody responses.
Conclusions:
- Mechanotransduction is critical for CD40 function during the germinal center reaction.
- Physical forces play a significant role in regulating B cell maturation and antibody production.
- Defective mechanobiology of CD40-CD40L interactions contributes to the pathogenesis of X-HIgM syndrome.
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