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Mechanical control of cell proliferation patterns in growing tissues
Logan C Carpenter1, Fernanda Pérez-Verdugo1, Shiladitya Banerjee1
1Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Biorxiv : the Preprint Server for Biology
|August 7, 2023
Summary
Tissue confinement and cell mechanics control tissue growth. Mechanical feedback enhances proliferation at boundaries, while cell properties regulate growth dynamics and patterns.
Area of Science:
- Computational biology
- Biophysics
- Developmental biology
Background:
- Cell proliferation is vital for tissue homeostasis and development.
- Controlling cell proliferation in dense tissues remains poorly understood.
Approach:
- Developed a computational framework linking single-cell behaviors to tissue growth.
- Incorporated probabilistic rules for cell growth, division, elimination, and mechanical feedback.
- Calibrated model parameters using experimental data.
Key Points:
- Tissue confinement suppresses cell growth and enhances apoptosis in dense regions.
- Mechanical feedback drives increased proliferation at tissue boundaries, arresting bulk growth.
- Cellular elasticity and contact inhibition regulate proliferation patterns.
Conclusions:
- Mechanical feedback and cell properties significantly impact spatiotemporal cell proliferation patterns.
- Computational models are crucial for understanding tissue growth dynamics.
- This study highlights the role of cell mechanics in tissue development.
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