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Related Experiment Videos

Long volume during high frequency oscillation.

A C Bryan, A S Slutsky

    The American Review of Respiratory Disease
    |May 1, 1986
    PubMed
    Summary
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    Gas trapping during high-frequency ventilation was not observed in normal or diseased lungs under standard conditions. However, trapping occurred at low mean airway pressures, suggesting choke points limit expiratory flow.

    Area of Science:

    • Respiratory physiology
    • Mechanical ventilation

    Background:

    • High-frequency oscillatory ventilation (HFOV) is used in critical care.
    • Concerns exist regarding potential gas trapping with HFOV.

    Purpose of the Study:

    • To investigate the conditions under which gas trapping occurs during HFOV.
    • To identify the mechanisms limiting expiratory flow at low lung volumes.

    Main Methods:

    • Gas trapping was assessed by comparing alveolar pressure (occlusion pressure) with mean airway circuit pressure.
    • Experiments were conducted on normal and lung-lavaged rabbits at varying frequencies (15 and 25 Hz).
    • Infants with infant respiratory distress syndrome were also studied.

    Main Results:

    • Gas trapping was not observed in rabbits or infants under normal operating conditions.

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  • Gas trapping was induced when operating at unusually low mean airway pressures.
  • Low lung volumes at low mean airway pressures are hypothesized to cause choke points that limit expiratory flow.

    • Conclusions:

    • Gas trapping during HFOV is not an inherent feature under normal settings.
    • Gas trapping can be provoked by low mean airway pressures, leading to reduced lung volumes.
    • The development of choke points at low lung volumes is the likely cause of limited expiratory flow and gas trapping.