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Brain structure alterations in girls with central precocious puberty.
Shoko Yoshii1, Tomozumi Takatani1, Tadashi Shiohama1
1Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Frontiers in Neuroscience
|August 7, 2023
Summary
Central precocious puberty (CPP) is linked to specific brain structural differences, notably increased right precuneus thickness. This finding may help explain the psychological outcomes associated with early puberty.
Area of Science:
- Neuroscience
- Pediatric Endocrinology
Background:
- Central precocious puberty (CPP) involves early onset of puberty with potential negative psychological effects.
- Limited research exists on the brain's structural characteristics in individuals with CPP.
Purpose of the Study:
- To investigate and identify structural brain differences in patients diagnosed with CPP.
- To explore the relationship between brain morphology and CPP.
Main Methods:
- Voxel- and surface-based morphometric analyses were conducted on T1-weighted brain MRI scans.
- 15 girls with CPP and 13 age-matched controls (NC) were included.
- Statistical analyses included Levene's test, unpaired t-tests, and Benjamini-Hochberg correction.
Main Results:
- Morphometric analysis revealed 33 candidate brain measurements.
- Patients with CPP showed increased cortical thickness in the right precuneus compared to controls.
- General linear models and neuroimaging maps visualized these differences.
Conclusions:
- Brain scans of CPP patients exhibit distinct morphological variations from controls.
- Identified brain morphology features in CPP may elucidate links to adverse psychological outcomes.
- Further research into brain structure can enhance understanding of CPP's impact.
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