Metabolic Syndrome and Assisted Reproductive Techniques

Area of Science:

• Reproductive Endocrinology
• Metabolic Disorders
• Infertility Research

Background:

• Metabolic syndrome is a known risk factor for reproductive health and pregnancy outcomes.
• The impact of metabolic syndrome on the success of assisted reproduction techniques (ART) remains under-investigated.

Purpose of the Study:

• To investigate the relationship between metabolic syndrome and ART success rates in infertile women.
• To determine if metabolic syndrome influences pregnancy achievement and early pregnancy outcomes.

Main Methods:

• A prospective cohort study involving 147 infertile women undergoing in-vitro fertilization/intra cytoplasmic sperm injection (IVF/ICSI) in Isfahan, Iran.
• Participants were divided into two groups: with metabolic syndrome (n=49) and without (n=98).
• Key metabolic indicators (BMI, waist/abdominal circumference, TG, cholesterol, FBS) were measured, and pregnancy outcomes were followed up to 20 weeks.

Main Results:

• The prevalence of metabolic syndrome among the study participants was 33.4%.
• No significant differences were observed in ART success rates, pregnancy rates (p=0.907), or abortion rates (p=0.896) between women with and without metabolic syndrome.
• Metabolic parameters did not significantly differ based on pregnancy or abortion occurrence.

Conclusions:

• Metabolic syndrome indicators showed no significant association with the success rates of achieving pregnancy through ART.
• The study found no significant difference in early pregnancy outcomes (up to 20 weeks) for women with or without metabolic syndrome undergoing ART.