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Diagnoses and medications associated with delayed ejaculation.

Evan Mulloy1, Amy Zhang1, Federico Balladelli1,2

  • 1Department of Urology, Stanford University School of Medicine, Palo Alto, CA, United States.

Sexual Medicine
|August 7, 2023
PubMed
Summary
This summary is machine-generated.

Delayed ejaculation (DE) is linked to various health issues and medications, including male infertility, anxiety, and antidepressant use. These findings may help understand DE causes and explore new treatment options.

Keywords:
Peyronie’s diseasedata miningejaculationerectile dysfunction

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Area of Science:

  • Urology
  • Men's Health
  • Clinical Data Mining

Background:

  • Delayed ejaculation (DE) is a distressing condition with largely unknown causes.
  • Clinical factors associated with DE remain poorly understood.

Purpose of the Study:

  • To identify health conditions and medications associated with DE using data mining.
  • To explore potential etiological factors for delayed ejaculation.

Main Methods:

  • Utilized an insurance claims database for a cohort study.
  • Employed random forest and LASSO for classification and variable selection.
  • Matched 11,602 men with DE to controls with erectile dysfunction (ED) and Peyronie's disease (PD).

Main Results:

  • Identified key factors associated with DE, including male infertility, testicular dysfunction, anxiety, lipid disorders, alpha-adrenergic blockers, anemia, antidepressants, and psychoses.
  • Found variations in condition prevalence across racial/ethnic groups, e.g., male infertility in Asian men.
  • Odds ratios indicated significant risk associations for identified factors.

Conclusions:

  • Multiple medical conditions and medications are associated with DE.
  • Findings offer insights into DE etiology and potential therapeutic targets.
  • Highlights the need for further research into DE's multifactorial nature.