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Cardiovascular health, infection burden, and incident dementia in the UK Biobank

Hind A Beydoun1, May A Beydoun2, Osorio Meirelles2

  • 1Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|August 7, 2023
PubMed

Insights

Infections, particularly hospital-treated ones, are linked to dementia risk in older adults. Cardiovascular health influences how total infection burden affects all-cause dementia.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Neurology

Background:

  • Infections are increasingly recognized as potential contributors to cognitive decline.
  • Cardiovascular health (CVH) plays a crucial role in brain health and dementia risk.

Purpose of the Study:

  • To investigate the association between infectious agents and the incidence of all-cause and Alzheimer's disease (AD) dementia.
  • To examine how cardiovascular health modifies these associations.

Main Methods:

  • Utilized Cox proportional hazards models on UK Biobank data (>355,000 participants ≥50 years).
  • Examined ICD-10-specific viral and bacterial infections.
  • Assessed cardiovascular health using the Life's Essential 8 (LE8) index.

Main Results:

  • Hospital-treated infections were significantly related to both all-cause and AD dementia.
  • Total infection burden was associated with all-cause dementia, but only in individuals with the lowest CVH (LE8 tertile).
  • Significant interactions between infection burden and LE8 tertiles were observed for all-cause dementia.

Conclusions:

  • Hospital-treated infections are a risk factor for dementia, including Alzheimer's disease.
  • Cardiovascular health is a modifying factor in the relationship between general infection burden and all-cause dementia.
  • Findings highlight the interplay between infection, cardiovascular health, and dementia risk in older adults.
Abstract

Keywords:
Alzheimer's diseasecardiovascular healthdementiahospitalizationinfection

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