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Updated: Jul 19, 2025

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

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Published on: September 23, 2013

Target-Specific Bioorthogonal Reactions for Precise Biomedical Applications.

Zhengwei Liu¹, Mengyu Sun^1,2, Wenting Zhang^1,2

¹Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.

Angewandte Chemie (International Ed. in English)

|August 7, 2023

Summary

This summary is machine-generated.

Targeted bioorthogonal reactions enable precise in situ drug synthesis for improved disease treatment. This review highlights strategies and applications for specific medical interventions, offering a future perspective on safe and efficient therapies.

Keywords:

Biomedical Applications Bioorthogonal Reactions Prodrugs Target Selectivity

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Area of Science:

Biomedical Engineering
Chemical Biology
Drug Delivery

Background:

Bioorthogonal chemistry facilitates studying biological processes in vivo.
In situ drug synthesis via bioorthogonal reactions shows potential for enhanced therapeutic efficacy and reduced side effects.
Precise localization of bioorthogonal reactions is crucial for targeted medical applications.

Purpose of the Study:

To review the design and development of targeted bioorthogonal reactions for precise medical treatments.
To compile strategies for achieving target-specific bioorthogonal reactions.
To emphasize the application of these reactions in treating various therapeutic targets.

Main Methods:

Literature review of recent strategies for targeted bioorthogonal reactions.
Analysis of applications in precise medical treatment.
Discussion of challenges and future directions.

Main Results:

Compilation of diverse strategies for target-specific bioorthogonal reactions.
Emphasis on successful applications in precise disease treatment.
Identification of key challenges and future research avenues.

Conclusions:

Targeted bioorthogonal reactions are vital for precise in situ drug synthesis and disease treatment.
Further research is needed to overcome challenges for safe, efficient, and translatable applications.
This field holds significant promise for the future of medicine.