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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Strategies for senolytic drug discovery.

Helen Power1,2,3, Peter Valtchev1,2, Fariba Dehghani1,2

  • 1Faculty of Engineering, School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, New South Wales, Australia.

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Senolytics are drugs that target cellular senescence, a key factor in aging and chronic diseases. This review categorizes known senolytics and screening methods, highlighting potential for new drug discovery.

Keywords:
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Area of Science:

  • Gerontology and Pharmacology
  • Cellular Biology and Aging Research

Background:

  • Cellular senescence contributes to chronic and age-related diseases.
  • The field of senolytics has rapidly expanded since 2015.
  • Senolytic drugs offer a therapeutic strategy to mitigate senescence-associated pathologies.

Purpose of the Study:

  • To review and categorize known senolytic agents.
  • To discuss methodologies for screening and identifying novel senolytics.
  • To highlight recent advancements and future directions in senolytic drug discovery.

Main Methods:

  • Categorization of senolytic agents including kinase inhibitors, Bcl-2 inhibitors, polyphenols, and others.
  • Analysis of diverse screening approaches, senescence induction methods, target cells, and assays.
  • Review of recent advances in single-cell analysis and computational identification methods.

Main Results:

  • A broad spectrum of senolytic drug categories has been identified.
  • Screening methodologies vary significantly, impacting outcome quality.
  • Robust screening requires validated systems, controls, and assays.

Conclusions:

  • Significant potential exists for discovering new senolytic drugs.
  • Further research into drug targets and mechanisms is crucial.
  • Rigorous preclinical and clinical evaluation is necessary for senolytic therapies.