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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Circadian clock disruption in autoimmune thyroiditis.

Jinrong Fu1,2, Zihao Fan3, Liang He4

  • 1Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

European Thyroid Journal
|August 7, 2023
PubMed
Summary
This summary is machine-generated.

Circadian clock disruption impairs autoimmune thyroiditis (AIT) by reducing clock gene expression and increasing inflammation. Maintaining regular circadian rhythms may help manage AIT.

Keywords:
autoimmune thyroiditisclock disruptionclock genesinflammation

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Area of Science:

  • Immunology
  • Endocrinology
  • Chronobiology

Background:

  • A link exists between circadian disruption and heightened immune responses in inflammatory diseases.
  • The role of circadian clock disruption in autoimmune thyroiditis (AIT) requires further investigation.

Purpose of the Study:

  • To explore the impact of circadian clock disruption on autoimmune thyroiditis.
  • To assess the relationship between clock gene expression and inflammatory markers in AIT.

Main Methods:

  • Thyroid tissues from AIT patients and controls were analyzed for core clock gene expression and inflammatory biomarkers.
  • Experimental autoimmune thyroiditis (EAT) was induced in mice to study circadian characteristics and the effects of light shift (LS) on EAT.

Main Results:

  • Reduced expression of BMAL1 and PER2 clock genes was observed in AIT thyroid tissues, correlating with thyroid peroxidase antibodies.
  • EAT mouse models showed diurnal fluctuations in proinflammatory cytokines; LS conditions exacerbated TNF-α, IFN-γ, and anti-thyroglobulin antibody production.
  • Significant oscillations of multiple clock genes (Bmal1, Clock, Per2, Cry1, Ror, Rev-erb) were disturbed in EAT, LS, and combined EAT + LS conditions.

Conclusions:

  • Clock gene expression patterns are disrupted in AIT thyroid.
  • Chronic circadian disruption may worsen inflammatory responses in AIT.
  • Further research is needed to determine if regular circadian rhythms can alleviate autoimmune thyroid diseases.