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Updated: Jul 19, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Proton pump inhibitors and the risk of acquiring a penicillin allergy label
Sarah Al-Obaydi1, Catherine A Popadiuk2, Taha Al-Shaikhly2
1Department of Medicine, Penn State College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA.
Abstract:
The negative consequences of having a penicillin allergy label are well established. Penicillin allergy de-labelling improves healthcare outcomes; however, less attention is paid to modifying risk factors leading to penicillin allergy development. In this propensity score-matched retrospective cohort study, we used a de-identified population-based database (TriNetX Research Network) and examined the 30-day risk of acquiring a penicillin allergy label in patients using proton pump inhibitors (PPIs). We demonstrated a higher risk of acquiring a penicillin allergy label among PPI users compared to controls.
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