Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

61
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
61

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect.

PloS one·2026
Same author

Gene therapy for aging and longevity.

Trends in molecular medicine·2026
Same author

Questions of the future in aging and longevity research at the GIMM Festival.

Nature aging·2026
Same author

Gene-expression patterns can be used to estimate mortality risk and chronological age.

Nature·2026
Same author

Markers of inflammation and lung function in liver transplant recipients: results from a nationwide cohort study.

Frontiers in immunology·2026
Same author

High cytomegalovirus antibody concentrations and lower lung function in persons with HIV who smoke.

Annals of the American Thoracic Society·2026

Related Experiment Video

Updated: Jul 19, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.9K

Transcriptomics age acceleration in prolonged treated HIV infection.

Flora Mikaeloff1, Marco Gelpi2, Alejandra Escos1

  • 1The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Aging Cell
|August 7, 2023
PubMed
Summary
This summary is machine-generated.

Biological aging in people with HIV (PWH) on antiretroviral therapy (ART) is complex. A transcriptomics age estimator revealed 43% experienced accelerated aging, linked to inflammation and immune responses, while 21% showed decelerated aging.

Keywords:
biological agingtranscriptomics aging clocktreated HIV infection

More Related Videos

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.3K
Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
10:12

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity

Published on: June 14, 2024

2.0K

Related Experiment Videos

Last Updated: Jul 19, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.9K
Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.3K
Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
10:12

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity

Published on: June 14, 2024

2.0K

Area of Science:

  • Biomedical Science
  • Genomics
  • Immunology

Background:

  • Biological aging in people with HIV (PWH) on long-term successful antiretroviral therapy (ART) remains poorly understood.
  • Immune reconstitution and viral suppression are key factors in PWH on ART.

Purpose of the Study:

  • To investigate the transcriptomics age estimator (TAE) in PWH on prolonged successful ART.
  • To identify clinical, demographical, and lifestyle factors associated with age acceleration or deceleration in PWH.

Main Methods:

  • Utilized a cohort of 178 PWH from the Copenhagen Comorbidity (COCOMO) cohort on prolonged successful ART.
  • Employed TAE and analyzed 143 clinical, demographical, and lifestyle factors.
  • Performed directionally class-based gene set enrichment analysis.

Main Results:

  • 43% of PWH exhibited accelerated aging (AAP), and 21% showed decelerated aging (DAP).
  • DAP was associated with older age, European ancestry, and tenofovir disoproxil/alafenamide fumarate use.
  • AAP showed upregulated inflammatory and immune response pathways, while DAP showed downregulated metabolic processes.

Conclusions:

  • Biological aging is heterogeneous in PWH on successful ART, with significant proportions experiencing accelerated or decelerated aging.
  • Transcriptomic analysis reveals distinct molecular pathways associated with accelerated (inflammation, immune response) and decelerated (metabolism) aging in PWH.
  • Understanding these aging patterns is crucial for managing long-term health in PWH.