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Related Experiment Video

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Generation of Alginate Microspheres for Biomedical Applications
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Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance.

Xiao Han1,2, Bingyang Lu2, Dan Zou2,3

  • 1Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.

ACS Applied Materials & Interfaces
|August 7, 2023
PubMed
Summary

This study developed an intelligent hydrogel coating for vascular stents that releases hydrogen sulfide (H2S) to combat inflammation and oxidative stress, improving stent safety and preventing in-stent restenosis.

Keywords:
H2Sallicinhydrogel coatingredox responsevascular implant

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Drug Delivery Systems

Background:

  • Coronary atherosclerosis involves inflammation and oxidative stress, complicating traditional stent treatments.
  • Current drug-eluting stents have limitations including poor biocompatibility, delayed healing, and late thrombosis.
  • The acidic and oxidative microenvironment in atherosclerosis presents an opportunity for targeted therapies.

Purpose of the Study:

  • To develop an intelligent, redox-responsive hydrogel coating for vascular interventional devices.
  • To incorporate hydrogen sulfide (H2S)-releasing allicin into a catechol hyaluronic acid (C-HA) and cystamine (Cys) hydrogel.
  • To evaluate the coating's potential for precise drug release in response to the atherosclerotic microenvironment.

Main Methods:

  • Prepared C-HA-Cys hydrogel coatings via amide reaction and loaded with allicin.
  • Designed the hydrogel to be redox-responsive, releasing H2S upon encountering inflammation and oxidative stress.
  • Assessed hemocompatibility, anti-inflammatory effects, cytocompatibility, and in vivo histocompatibility.
  • Investigated the impact of released H2S on atherosclerosis-related signaling pathways (CD31, CSE, CD36, ACAT-1).

Main Results:

  • The C-HA-Cys-Allicin hydrogel coating demonstrated good hemocompatibility, anti-inflammatory capacity, and cytocompatibility.
  • The coating exhibited redox-responsive drug release, triggered by the inflammatory microenvironment.
  • In vivo studies confirmed favorable histocompatibility and demonstrated the H2S release modulated key atherosclerosis pathways.
  • The hydrogel coating showed potential in preventing in-stent restenosis.

Conclusions:

  • The developed intelligent hydrogel coating offers a precise, microenvironment-responsive drug delivery system for vascular devices.
  • This technology has the potential to enhance the safety and efficacy of interventional treatments for coronary atherosclerosis.
  • The H2S-releasing capability addresses limitations of traditional stents by mitigating inflammation and promoting healing.