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Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

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Silk-protein-based gradient hydrogels with multimode reprogrammable shape changes for biointegrated devices.

Yushu Wang^1,2, Luhe Li¹, Yue-E Ji¹

¹National Laboratory of Solid State Microstructures, Key Laboratory of Intelligent Optical Sensing and Manipulation, College of Engineering and Applied Sciences, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.

Proceedings of the National Academy of Sciences of the United States of America

|August 7, 2023

Summary

This summary is machine-generated.

Researchers developed a novel method using electric fields to program silk protein hydrogels for adaptive shape changes. This technique offers a simple, energy-efficient approach for creating advanced biomaterials for biomedical applications.

Keywords:

electrical hydrogel interface shape-change silk

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Area of Science:

Biomaterials Science
Polymer Chemistry
Bioelectronics

Background:

Morphable hydrogels are valuable for biomedical applications but often require complex fabrication.
Existing methods for shape-changing hydrogels are energy-intensive and cumbersome.

Purpose of the Study:

To develop a simple, electric-field-activated strategy for programming silk-protein hydrogels with controllable shape transformations.
To enable reprogrammable and adaptive shape changes in hydrogels for biomedical uses.

Main Methods:

Utilized an electric-field-activated protein network migration strategy in silk-protein hydrogels.
Generated a pH gradient using a low electric field to induce protein network convergence.
Controlled shape transformations through polymorphic transitions for reprogramming or permanent fixation.

Main Results:

Achieved controllable and reprogrammable complex shape transformations in silk-protein hydrogels.
Demonstrated the formation of gradient network structures enabling three-dimensional shape change.
Successfully interfaced morphing hydrogels with biological tissues and created an implantable bioelectronic device.

Conclusions:

The electric-field-activated strategy provides a simple and efficient method for creating advanced morphable hydrogels.
These reprogrammable silk-protein hydrogels show significant potential for diverse biomedical applications, including bioelectronic devices.