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Silver electroceutical technology to treat sarcopenia.

Min Young Kim1, Hyun Young Shin2,3, Sung Chun Cho4

  • 1Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.

Proceedings of the National Academy of Sciences of the United States of America
|August 7, 2023
PubMed
Summary

This study introduces a novel silver electroceutical technology for treating sarcopenia. Electrical stimulation (ES) effectively rejuvenated aged skeletal muscle cells (skMCs) in vitro and in vivo, offering a promising personalized treatment.

Keywords:
electroceuticalintegrated electrical stimulation biochipmultiplex screening technologypersonalized electric medicinesarcopenia

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Area of Science:

  • Biomedical Engineering
  • Gerontology
  • Regenerative Medicine

Background:

  • Sarcopenia, muscle loss in aging, lacks effective pharmaceutical treatments.
  • Electrical stimulation (ES) is a potential alternative for sarcopenia, but its efficacy is unproven.
  • Targeting skeletal muscle cells (skMCs) specifically is crucial for effective sarcopenia treatment.

Purpose of the Study:

  • To investigate the efficacy of electrical stimulation (ES) for treating sarcopenia.
  • To develop and validate a silver electroceutical technology for sarcopenia.
  • To explore personalized bioelectronic medicine approaches for age-related muscle decline.

Main Methods:

  • Developed a high-throughput ES screening platform for simultaneous testing of 15 conditions.
  • Utilized human-derived primary aged and young skeletal muscle cells (hAskMC/hYskMC) for in vitro screening.
  • Applied optimized ES conditions in vivo to aged mice models.

Main Results:

  • Specific ES conditions induced hypertrophy and rejuvenation in aged human skMCs (hAskMCs) in vitro.
  • Optimal ES frequency differed between aged and young skMCs.
  • In vivo ES improved Type IIA fiber prevalence and thickness, enhancing biomechanical attributes in aged mice, mimicking a younger skMC phenotype.

Conclusions:

  • Silver electroceutical technology shows potential for sarcopenia treatment.
  • ES can induce rejuvenation and improve muscle function in aged skMCs.
  • This approach may lead to personalized electroceutical treatments for sarcopenia with minimal side effects.