Related Experiment Video

Updated: Jul 19, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

214

New Paradigms for CKD Management in Patients With T2D

Joshua J Neumiller, Stephen A Brunton

    The Journal of Family Practice
    |August 7, 2023
    PubMed
    Abstract

    Insights

    Patients with type 2 diabetes (T2D) face significant kidney disease risks. This activity covers screening, evidence-based therapies, and the role of finerenone in managing chronic kidney disease (CKD) in T2D.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Pharmacology

    Background:

    • Type 2 diabetes (T2D) is a leading cause of chronic kidney disease (CKD).
    • Diabetic kidney disease (DKD) significantly increases morbidity and mortality.
    • Early detection and intervention are crucial for managing DKD progression.

    Purpose of the Study:

    • To educate healthcare professionals on identifying CKD risks in T2D patients.
    • To outline appropriate screening strategies for CKD in T2D.
    • To review evidence-based treatments for slowing DKD progression, including novel agents like finerenone.

    Main Methods:

    • Review of current clinical guidelines and landmark trials.
    • Discussion of diagnostic criteria and screening protocols for CKD in T2D.
    • Analysis of the mechanism of action and clinical data for finerenone.

    Main Results:

    • Understanding the multifactorial risks and consequences of kidney disease in T2D.
    • Proficiency in screening for CKD using established biomarkers and diagnostic tools.
    • Knowledge of therapeutic strategies to mitigate DKD progression.

    Conclusions:

    • Effective management of T2D and CKD requires a comprehensive approach.
    • Finerenone represents a significant advancement in treating T2D with CKD.
    • Continuous medical education is vital for optimizing patient outcomes in DKD.

    More Related Videos

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    709
    Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

    Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

    Published on: April 12, 2021

    4.4K

    Related Concept Videos

    Chronic Kidney Disease III: Interprofessional Care01:28

    Chronic Kidney Disease III: Interprofessional Care

    Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
    42
    Chronic Kidney Disease IV: Nursing Management01:18

    Chronic Kidney Disease IV: Nursing Management

    Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
    25
    Diabetes: Management and Pharmacotherapy01:15

    Diabetes: Management and Pharmacotherapy

    The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
    Insulin remains the cornerstone of treatment for most patients with type 1 and many...
    311
    Diabetes Mellitus: Type 2 and Gestational01:22

    Diabetes Mellitus: Type 2 and Gestational

    Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
    2.5K
    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
    30
    Chronic Kidney Disease I: Introduction01:25

    Chronic Kidney Disease I: Introduction

    Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
    36