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Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

677
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
677
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

458
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
458
Analgesia and Pain Management01:25

Analgesia and Pain Management

657
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
657
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

618
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
618

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Related Experiment Video

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Development of Recombinant Proteins to Treat Chronic Pain
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Percutaneous Spinal Interventions for Chronic Pain Management.

Robert McCormick1, Sunali Shah1

  • 1Department of Neurology, Boston Medical Center, Boston, Massachusetts.

Seminars in Neurology
|August 7, 2023
PubMed
Summary

Interventional procedures offer effective management for chronic neck and back pain, including conditions like cervical and lumbar radiculopathy. Understanding their benefits and risks is key to improving patient quality of life through multimodal pain management.

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Area of Science:

  • Pain Management
  • Neurosurgery
  • Orthopedics

Background:

  • Chronic neck and back pain, including cervical/lumbar radiculopathy, spinal stenosis, and facet arthropathy, are prevalent disabling conditions.
  • Current treatment paradigms encompass nonpharmacological, pharmacological, surgical, and interventional approaches.

Conclusions:

  • Interventional procedures are a vital component of managing chronic neck and back pain.
  • A comprehensive understanding of interventional options supports their integration into multimodal pain management plans.
  • Effective pain management through these approaches can lead to improved patient quality of life.