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Cholecystokinin secretion after oral Emtobil, a gallbladder-contracting formula
Scandinavian Journal of Gastroenterology
|March 1, 1986
Summary
Oral Emtobil, a sorbitol and peanut oil preparation, effectively stimulates gallbladder contraction by releasing cholecystokinin (CCK). This study measured significant CCK plasma level increases after Emtobil intake, suggesting its use in CCK secretion tests.
Area of Science:
- Gastroenterology
- Endocrinology
- Radiology
Background:
- Oral Emtobil, a sorbitol and peanut oil preparation, is utilized in radiological practice for gallbladder imaging.
- Gallbladder contraction is primarily mediated by cholecystokinin (CCK), a key gastrointestinal hormone.
Purpose of the Study:
- To investigate the effect of oral Emtobil on plasma cholecystokinin (CCK) concentrations in healthy subjects.
- To evaluate the potential of Emtobil as a stimulus for CCK secretion testing.
Main Methods:
- Radioimmunoassay was employed to quantify sulphated CCK-8 and CCK-33 in plasma samples.
- Plasma CCK levels were measured in nine healthy, fasting subjects before and after oral administration of 100 ml Emtobil.
Main Results:
- Fasting plasma CCK levels averaged 1.2 pmol/l.
- A significant peak plasma CCK concentration of 8 pmol/l was observed within 30 minutes post-Emtobil ingestion.
- Emtobil administration led to a rapid and substantial increase in circulating CCK.
Conclusions:
- Oral Emtobil induces gallbladder contraction through the release of cholecystokinin (CCK).
- The pronounced and rapid elevation in plasma CCK levels suggests Emtobil's utility in diagnostic tests assessing CCK secretion.