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Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity

Takuya Okada1, Kaho Yamabe2, Michiko Jo3

  • 1Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan; Graduate School of Pharma-Medical Sciences, University of Toyama, Toyama 930-8555, Japan; Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.

Bioorganic & Medicinal Chemistry Letters
|August 7, 2023
PubMed

Keywords:
Docking-simulationGLS1 inhibitorGlutaminaseStructure–activity relationshipThiaziazole

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