Cellular responses in crustaceans under white spot syndrome virus infection

Innate immunity plays the most important system responsible for protecting crustaceans against invading pathogens. White spot syndrome virus (WSSV) is considered a serious pathogen in crustaceans with high cumulative mortality and morbidity in infected animals. Understanding the mechanism of the response of hosts to WSSV infection is necessary, which is useful for effective prevention in controlling infection. In this review, we summarize the participation of signaling pathways (toll, immune deficiency, JAK/STAT, endocytosis, mitogen-activated protein kinase, PI3K/Akt/mTOR, cGAS-STING, Wingless/Integrated signal transduction, and prophenoloxidase (proPO) cascade) and the activity of cells (apoptosis, autophagy, as well as, reactive oxygen species and antioxidant enzymes) in the cellular-mediated immune response of crustaceans during WSSV infection. The information presented in this current review is important for a better understanding of the mechanism of the response of hosts to pathogens. Additionally, this provides a piece of basic knowledge for discovering approaches to strengthen the immune system and resistance of cultured animals against viral infections.