Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Arteries of the Lower Limbs

Arteries of the Lower Limbs

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phase-dependent stimulation response is shaped by the brain's dynamic functional connectivity.

Network neuroscience (Cambridge, Mass.)·2026

Same author

Dynamics of the attentional blink in preverbal infants.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

AI-Generated Scientific Papers: Crisis? What Crisis?

eNeuro·2026

Same author

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology.

Epilepsia·2026

Same author

The accumulation of extracellular K<sup>+</sup> as in vivo model of epilepsy in CA1 pyramidal neurons.

Scientific reports·2025

Same author

Optimal Inhibitory-to-Excitatory Ratio Governs Slow and Fast Oscillations for Enhanced Neural Communication.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Perturbed Information Processing Complexity in Experimental Epilepsy.

Wesley Clawson^1,2, Benjamin Waked³, Tanguy Madec³

¹Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France wesley.clawson@tufts.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|August 7, 2023

Summary

This summary is machine-generated.

Epilepsy permanently alters neural dynamics supporting cognition. This study reveals disrupted information processing in the hippocampus and entorhinal cortex, potentially explaining cognitive deficits in epilepsy patients.

Keywords:

algorithm complexity entorhinal cortex epilepsy hippocampus information processing

More Related Videos

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Related Experiment Videos

Last Updated: Jul 19, 2025

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Area of Science:

Neuroscience
Computational Neuroscience
Epilepsy Research

Background:

Cognitive deficits are common, persistent comorbidities in epilepsy.
Neural dynamics supporting cognition may be permanently altered in epilepsy, beyond transient seizures.

Purpose of the Study:

To investigate if fundamental information processing (storage and sharing) is disrupted in the hippocampus and entorhinal cortex in experimental epilepsy.
To determine if these disruptions contribute to epilepsy-associated comorbidities.

Main Methods:

Experimental epilepsy model in adult, male Wistar rats.
Analysis of neural dynamics during slow and theta oscillations in the hippocampus and entorhinal cortex.
Assessment of information storage and sharing mechanisms within neural states.

Main Results:

Information storage and sharing are organized into substates during brain oscillations in both epileptic and control rats.
Epilepsy disrupts the composition and temporal organization of these information processing substates.
Disrupted neural dynamics in epilepsy show reduced brain state selectivity and increased disorder.

Conclusions:

Alterations in information processing at the algorithmic level may underlie cognitive comorbidities in epilepsy.
Disrupted neural computation in the hippocampus and entorhinal cortex could be a key mechanism for widespread performance impairments.
This algorithmic disruption offers a potential link between brain structure/function and epilepsy-related cognitive deficits.